Categorías:
Ciencias
Etiquetas:
Bioinformatics
Data Science
Drug repurposing
Network pharmacology
Systems Medicine

Dentro del ciclo de seminarios del Centro de Tecnología Biomédica, el 20 de septiembre de 2022 contaremos con la presencia del Dr. Harald Schmidt, que impartirá la conferencia titulada: 

The end of medicine as we know it - And why our health has a future

We do not understand the causality of almost any human disease and thus declare them as chronic and complex. Instead of treating causes we must treat symptoms, which is highly ineffective. For so-called complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in a constant decline. To this, reproducibility issues with almost 60% of all biomedical publications and wrong incentives such as the obsession with high impact factor papers contribute. The biggest conceptual error in Medicine was to split up the human body organ by organ, including organ-specific research disciplines and to pretend one can define a disease within one organ. Systems Medicine overcomes this roadblock by re-integrating the human body in an evidence-based manner enabled by data science and bioinformatics. Systems medicine’s therapeutic arm, network pharmacology, revolutionizes how we define, diagnose, treat, and ideally cure diseases. Descriptive disease phenotypes are replaced by mechanistic endotypes defined by causal, multi-target signaling modules that also explain respective comorbidities. These modules are however distinct from classical pathways, which we now recognize to be not more than highly curated mind maps of signaling events. Such modules often contain several fragments of several different canonical pathways. Precise and effective therapeutic intervention is subsequently achieved by synergistic multi-compound network pharmacology, ideally through drug repurposing, obviating the need for drug discovery, and speeding up the clinical translation. Network pharmacology is, however, not to be confused with the current combination therapies with multiple non-synergistic drugs targeting non-causal proteins that rather treat symptoms but do not cure disease. Eventually, how we conduct biomedical research, define signalling, diagnose and treat diseases, and practice medicine and will radically change.

Fechas En hora local del evento

Sep '22

20

11:00 Fecha de inicio

Sep '22

20

12:00 Fecha de fin

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