Schedule En hora local del evento

El Dr. Pierre Joseph, responsable del equipo “Micro-Nanofluidics for Life science and Environment" del “LAAS-CNRS” de Toulouse, presentará las líneas de investigación que se están desarrollando en su grupo en el marco del proyecto europeo MSCA-SE SameMultiPhys ("Novel Biophysical Tools to Measure Multiple Parameters In The Same Cell").

Summary: MIcro-Nanofluidics for Life science and Environment - MILE

The MILE team  leverages microfluidic technologies to address key biophysical questions, focusing on the interplay between permeability, mechanical properties, and biological activity in tissues and cells. Their research spans diverse applications, from understanding the role of mechanics in cancer progression to cell filtration and sorting in blood.

Their work involves developing microfluidic tools to study essential biophysical properties of cells and tissues. This includes investigating the barrier and immunomodulatory functions of blood and lymphatic vessels through organ-on-chip systems, measuring the mechanical properties of multicellular aggregates and their interactions with nanoparticles via innovative micropipette-based fluidic tools, and designing platforms for purifying cells and extracellular vesicles while analyzing their nucleic acid content. Additionally, they explore how spatial confinement influences cell behavior, providing insights into how physical constraints affect cellular physiology. Finally, their research on microfluidic filtration models helps unravel microscale filtration mechanisms and bio-clogging, advancing the understanding of biological filtration processes.

Project description: MSCA-SE SameMultiPhys

Physical forces and mechanical properties influence the behaviour, function, and development of cells and organisms. Biophysical biomarkers, including the ability of a cell to deform under pressure, highlight vital changes in disease progression and can be used for early disease detection. Despite current microfluidic techniques allowing high-throughput measurements, they fall short in providing comprehensive, multi-feature data from the same cell, hindering insights in mixed cell populations. Funded by the Marie Skłodowska-Curie Actions programme, the SameMultiPhys project aims to create custom microfluidic systems capable of measuring multiple cellular features simultaneously. The work is expected to deepen the understanding of cell mechanobiology, advancing biomarker identification for improved diagnostics.

 

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