Categorías:
Biotecnología
Ingeniería de materiales
Investigación médica
Biología
Ciencias
Etiquetas:
nanotechnology
Organ-on-a-chip devices
Sensor technology
Tissue engineering

Dentro del ciclo de seminarios del Centro de Tecnología Biomédica, el lunes 12 de septiembre el Dr. Javier Ramón Azcón impartirá la charla titulada:

"Training-on-a-Chip: a multi-organ device to  study the effect of muscle exercise on insulin secretion in vitro".

Unraveling the mechanisms leading to type 2 diabetes (T2D) is fundamental in searching for new molecular drugs to prevent and control this disease. Organ-on-a-chip (OOC) devices offer new T2D disease modeling and drug discovery approaches by providing biologically relevant models of tissues and organs in vitro integrated with biosensors. Miniaturized biosensors systems and advanced tissue fabrication procedures enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications. In this work, we have fabricated a biomimetic multi-OOC integrated device composed of skeletal muscle and pancreatic cells to study the impact of exercise on insulin secretion. Both engineered tissues are integrated with optical biosensing technology to monitor contraction-induced myokine secretion and their effect on beta-cells insulin production (fig. 1). Our cross-talk platform would improve drug test approaches and provide a new model to study the loss of pancreas functionality associated with T2D.

 

Fechas En hora local del evento

Sep '22

12

11:00 Fecha de inicio

Sep '22

12

12:00 Fecha de fin

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